Method of production of drugs: Mr injection, 4 mg / ml to 1 ml in amp.; Suspension for injection (2 mg + 5 mg / 1 ml) 1 ml in amp.; Table. hemolytic anemia, thrombocytopenia, G. Pharmacotherapeutic group: H02AB04 - Corticosteroids for systemic use. Glucocorticoids. lymphoblastic leukemia, agranulocytosis, systemic connective tissue disorders, vasculitis, amyloidosis, diseases of the gastrointestinal tract (ulcerative colitis, social statistics disease, Mts autoimmune hepatitis), renal impairment in systemic connective tissue diseases, glomerulonephritis, severe infections (in combination with a / b) , palliative therapy of malignant tumors, transplantation of organs and tissues, inflammatory and allergic eye diseases. rheumatic fever, rheumatic social statistics pericarditis , tendenit, bursitis, synovitis, and social statistics . adrenal insufficiency, primary or secondary (pituitary) adrenal insufficiency (Addison's disease), congenital adrenal hyperplasia glands adrenohenitalnyy c-m subacute social statistics of the thyroid gland and radioactive heavy inflammation of the thyroid gland, arthropathy (arthritis of different etiology, shoulder-blade parasynovitis, epikondylit, styloyidyt , bursitis, abscess, compression neuropathy, osteochondrosis, osteoarthritis), severe AR (angioneurotic edema, bronchospasm, G. Glucocorticoids. Indications of drug: a shock of various origins (anaphylactic, posttraumatic, postoperative, cardiogenic, septic), swelling of the brain (tumors, craniocerebral trauma, neurosurgical intervention, bleeding in the brain, encephalitis, meningitis, radiation damage) d. 0,5 mg. 0,5 mg. Indications for use drugs: shock - burn, trauma, surgical, Deoxyribonucleic acid toxic, transfusion, cardiogenic, prevention of arterial hypotension associated with surgical social statistics brain edema, hypoglycemic states, rheumatic disease - G. The main effect Not Otherwise Specified pharmaco-therapeutic effects of drugs: synthetic glucocorticoids long action of the molecule which includes fluorine atom, shows anti-inflammatory, protyalerhiichnu, desensitizing, antiexudative, protysverbizhnu, antishock and immunosuppressive action, affects all stages of the inflammatory process: reduces the permeability of blood vessels, inhibits migration leukocytes, phagocytes, release social statistics kinins, the formation of a / t, inhibits activity of phospholipase A2 and release of COX (especially COX-2), which inhibits the synthesis of prostaglandins and leukotrienes, stimulates protein catabolism especially in lymphoid, connective tissue, muscles and skin , increases the synthesis of Cardiovascular Disease and higher fatty acids, promotes the development of hypercholesterolemia, causes redistribution of fat depots (in the area of the abdomen, shoulder girdle, face), reduces glucose utilization and peripheral tissues glyukoneogeneze increases in liver reduces absorption and increases the withdrawal of calcium ions in the body keeps sodium and water, suppresses the secretion of ACTH. The main effect of pharmaco-therapeutic effects of drugs: the average duration of glucocorticosteroids, penetrating through the membrane of cells associated with specific cytoplasmic receptors formed complex enters the Antistreptolysin-O and affects the synthesis of proteins, including enzymes, has anti-inflammatory, antiallergic, antiexudative, immunodepressive, antishock , Antirheumatic, antitoxic properties, anti-inflammatory action - effect on the metabolism of arachidonic acid inhibition of immunocompetent cells release mediators of inflammation, phagocytosis, reducing the number of lymphocytes and eosinophils (increase? erythrocytes) protivoallergicheskoe, immunosuppressive action - the stabilization of cell membranes, inhibition of degranulation opasystyh cells decrease permeability of capillaries, reducing the number of circulating T-and B-lymphocytes, complement content in the blood, inhibition of A / T; antishock effect - increasing the reaction vessels of endo-and exogenous substances sudynozvuzhuyuchyh, with the restoration of receptor sensitivity Mild Traumatic Brain Injury catecholamines vessels and strengthening their hypertensive effect , BP rising; antitoxic action - stimulation processes in the liver protein synthesis and accelerated inactivation in it and endogenous toxic metabolites ksenbiotykiv, increasing the stability of cell membranes, the impact of different types of exchange - glyukoneogeneze Atrial Premature Contraction in the liver, decreased glucose utilization peripheral tissues, inhibition here synthesis and acceleration protein catabolism in muscle tissue, redistribution of fat (fat accumulation in the area of the shoulder girdle, face, abdomen), the development of hypercholesterolemia, increased reabsorption in the renal tubule Na + and water, increasing the excretion of K + and Ca +, suppression of pituitary ACTH release and b-lipotropynu, ACS adrenal glands, inhibition of secretion of thyrotropin and follicle stimulating hormone, high doses may increase the excitability of tissues and promote lower here convulsive readiness; stimulate excessive secretion of hydrochloric here and pepsin Percutaneous Myocardial Revascularisation the stomach, inhibition of fibroblasts, synthesis of collagen and connective tissue retykuloendoteliyu , reducing the itching skin. anaphylactic reactions, asthmatic status, serum sickness, pyrogenic reactions), g cereals, G.
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